Pazuzu is the god of the southwest wind known for bringing famine during dry seasons, and locusts during rainy seasons. Recent research suggests Pazuzu may have been associated with a cold, northeasterly wind. Pazuzu was said to be invoked in amulets which combat the powers of the malicious goddess, and hated rival, Lamashtu, who was believed to cause harm to mother and child during childbirth. Although Pazuzu is, himself, an evil spirit, he drives away other evil spirits, thus protecting humans against plagues and misfortunes.
After defeating the Minotaur in the Devil Busters game, the protagonist finds a strange statue in the game and unseals it, revealing Pazuzu. Pazuzu reveals that he is a servant of God and that the hero and his friend are the Messiahs destined to save the world from the demons that came through a rift created during the nuclear war 35 years prior. Giving the protagonist a handheld computer and the Demon Summoning Program, Pazuzu warns about demons invading the shelter before departing. Once they reach the surface, Pazuzu commands that the two join with his servant Orthrus at the Princess Hotel in Shinagawa, and head to the ruins of Tokyo Tower after a witch who betrayed him. The witch reveals that Pazuzu is simply using the two to gain power over Bael and the protagonist agrees with her, causing the friend, who is still loyal to Pazuzu, to depart with Orthrus. It is later revealed that Pazuzu is truly aligned with God and the other demons view him as a traitor because of this. The hero and the witch end up having to defeat and behead him in order to pass onwards.
Pazuzu is the demon ally of DB Mikanagi. He appears as a regular mob in the temple area of Ueno's Mirage gold level instance and as one of the supporting mobs in Samael's boss room in the gold level of Shinagawa's Catacombs of the Templar Knight.
"The Babylonian lord of wind and scorching sands. He has the body of a man, a lion's head, the claws and wings of an eagle, and has a deadly poison. The diseases he spreads can only be cured with magic."
—Persona 5 background
Pazuzu is the fifth Persona of the Devil Arcana and can only be obtained through fusion in the Velvet Room. He is one of three Personas to learn the Bad Beat skill and the first Persona that the protagonist can use in battle to use Eigaon. When itemized through Electric Chair execution, Pazuzu yields a Maeiga skill card.
Pazuzu can be used to help pass the High Counter skill on to Seth should the protagonist not possess a High Counter skill card. Fusing the Lachesis and Neko Shogun from the StrengthConfidant's earlier requests will produce Pazuzu. Leveling a Dakini to learn High Counter and fusing her with Pazuzu will result in a Horus that knows High Counter which can be used to complete the request for Caroline and Justine.
Pazuzu is the leader of the Imperium forces on Jin's route. He is faced in the Dark Palace and his role is similar to Scathach. Unlike her he does not put Akira to sleep before the battle. After the battle he flees with Jin following him. The others attempt to follow as well but the doors close. He has Rand sacrificed to the seal that holds his master Belzebu and forces Jin to release him. Pazuzu is killed by his master after he is freed as he has served his purpose.
Pazuzu is the Demon Companion for Tadashi Nikaido. He can only be fused under certain conditions. This demon can be unlocked either by defeating Pazuzu before defeating Kaido on the 5th Day (if the player fails to save Keisuke Takagi from being killed by Kaido), or by initiating Naoya's ending through speaking to Kaido first.
"The evil Babylonian lord of southeastern wind and scorching sands. He has a lion's head and arms, a human body, eagle-clawed feet, bird wings, and a scorpion's tail. He also has an oddly bent horn on his forehead. It's said he comes alongside the poisonous, scorching winds from the Persian Gulf to spread plague."
"A demon lord of southeast winds and scorching sands from Sumerian lore. He's a vile demon with the head and arms of a lion, the body of a human, birdlike wings, hawk like talons, a poisonous tail like a scorpion, and a strange horn protruding from his head. Pazuzu rides the warm winds from the Persian Gulf spreading diseases that can only be cured by magical means."