Also known as Anesidora she is the first human woman of Greek mythology, being born from clay. The gods gave her a husband and several gifts, including a jar (or a box in modern interpretations) which she was warned not to open. Tempted, she opened the jar, which unleashed all of the evils of mankind. Only hope remained in the jar after she closed it.
Pandora is Maki Sonomura's ultimate expression of nihilism. After the death of Takahisa Kandori, Aki awakened Pandora only to have Pandora devour her, destroying her half of the other Mikage-cho in the process. Pandora then proceeded to steal the core of the DEVA System from the real world. After the protagonist and the "Ideal Maki" come in contact with the soul of the "real" Maki in the Sea of Souls and receive her compact, the party is able to enter the Avidya World and confront Pandora, who plans to use the DEVA System core in a bid for destruction of all reality. After she is defeated, she questions how the party could be so powerful, and is reminded that they are fighting together as friends and that she isn't alone. Her and the Ideal Maki then merge, and one by one the party members are sent back to the real world. As Pandora represents the negative and repressed qualities of her host and can be accepted and reformed, she can be considered as a prototype of a Shadow Self.
She manifests as a monstrous, multi-limbed lump of flesh with Maki's head poking out of the main body, although after this form is defeated it is revealed to be a cocoon for her true form, which appears as a giant version of Maki with butterfly wings and antennae.
She is also one of the few demons weak to Amon-Ra's (the protagonist's ultimate Persona) signature attack, Hieroglyphein. This could symbolize the protagonist and Maki's friendship overcoming her nihilism.
Pandora is a member of the Tyrant Order in Megami Ibunroku Persona, but her Order was changed to Deity in both the Japanese and English versions of Shin Megami Tensei: Persona.