Next Gene appears on the 5th and 6th Path of Yomotsu Hirasaka within the Midnight Channel. It will attempt to Silence the party before attacking. After being defeated, it may drop an Unknowable Fiber. Selling 10 Unknowable Fibers at the TV extension of Daidara will unlock the Emery Meisen female armor.
Next Gene appears on the 3rd Block of the Theater District. It attacks with single-target Nuclear and Bless skills, and may increase its Hit/Evasion for three turns. When defeated, it may drop Gene Cache and Gene DNA. Gene Cache is used to create the Yume-no-Hashi for Yukiko. Gene DNA is used to create the Warlord Hammer for Shinjiro, the Christ Mirror for Kanji, and the Eternity Dress armor for females.