The Creation Relic appears in the lower floors of the Yabbashah Block in Tartarus, from the 65th to 77th floors. It is also the target of one of Elizabeth's requests, and will drop Relic Fragments until the request is completed. Five Relic Fragments are needed to complete the request.
The Creation Relic appears on the 1st through 4th floors of Marukyu Striptease within the Midnight Channel. It will attempt to affect all party members with Old One before attacking. Upon being defeated, it may drop the Hard Rock material. Selling 6 Hard Rocks at Daidara will unlock the Kozuka weapon for Yosuke Hanamura.
In Golden, the Creation Relic also drops Fluorite for trade in Shiroku Pub.
The Creation Relic appears in the 3rd Ave of the first Theater, Kamoshidaman. It will either hit the party with normal attacks or attempt to use Perplex Flash to inflict Confusion on one party member. The Statue Hinges it drops are used to make the Hell Slugger for Ryuji. Its rarer Statue Jewel drop is used to produce the Meteorite Katana for Yusuke along with the Kikuichimonji.