Change Relic appears as a sub-boss found on the 36th floor of Tartarus. It impedes the player's progress and must be beaten to proceed. The protagonist may make use of Fortuna's Wind resistance for this battle, as she can be fused from the Chimera and Inugami cards collected during Shuffle Time in the Arqa Block once the protagonist reaches Level 17. Alp may also be collected during Shuffle Time as a weaker alternative. The Change Relic will also make frequent use of its Poison Mist skill, so having Dis-Poisons on hand will mitigate the problem it poses. Also, once the protagonist reaches Level 17, the Wind Charm accessory becomes available at Be Blue V for 7,000 yen, which can be used to bolster Junpei Iori with the Dodge Wind ability.
In The Answer of Persona 3 FES, it appears as a regular enemy in Empyrean.
Change Relic appears in the 1st Block of the Theater District. It attacks with heavy, single-target Physical skills, can lower the party's defense, and may Hex a target. When defeated, it may drop Statue Cache and Statue Gold Foil. Statue Cache is used to create the Judge of Hell for Naoto, and the Full Jin-Baori male armor. Statue Gold Foil is used to create the Blue Rose Whip for Ann, the Samonji for Yusuke, the Amakuni for the P3 hero, The Ripper for Teddie, and the Wisdom Shield for Kanji.